A surprise with MuSK antibodies

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Myasthenia gravis patients with anti-MuSK antibodies.

In myasthenia gravis (MG) patients without detectable anti-acetylcholine receptor (anti-AChR) antibody, referred to as seronegative myasthenia gravis patients, there is a variable proportion of patients with antibodies against the muscle-specific kinase (MuSK). MuSK antibodies were found in 8 (29.6%) of our 27 patients with generalized MG without anti-AChR antibodies. All these patients were fe...

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Vocal cord paralysis as a manifestation of myasthenia gravis with anti-MuSK antibodies

the dorsal pons. There was no apparent compromise of the abducens nucleus or the paramedian pontine reticular formation, as in the case we present. In our case, independent from impairment of the medial longitudinal fasciculus, the nucleus raphe interpositus ventral to that structure may be 4. Milea D, Napolitano M, Dechy H, Le Hoang P, Delattre JY, Pierrot-Deseilligny C. Complete bilateral hor...

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Vocal cord paralysis as a manifestation of myasthenia gravis with anti-MuSK antibodies.

1. Wall M, Wray SH. The one and a half syndrome, a unilateral disorder of pontine tegmentum: a study of 20 cases and review of the literature. Neurology. 1983;33:971—80. 2. Bourre B, Collongues N, Bouyon M, Aupy J, Blanc F, Speeg C, et al. A case of bilateral horizontal gaze ophthalmoplegia: the 1 + 1 syndrome. Rev Neurol (Paris). 2010;166:1028—31. 3. Tan E, Kansu T. Bilateral horizontal gaze p...

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Differential Cytokine Changes in Patients with Myasthenia Gravis with Antibodies against AChR and MuSK

Neuromuscular transmission failure in myasthenia gravis (MG) is most commonly elicited by autoantibodies (ab) to the acetylcholine receptor or the muscle-specific kinase, constituting AChR-MG and MuSK-MG. It is controversial whether these MG subtypes arise through different T helper (Th) 1, Th2 or Th17 polarized immune reactions and how these reactions are blunted by immunosuppression. To addre...

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ژورنال

عنوان ژورنال: Neurology - Neuroimmunology Neuroinflammation

سال: 2019

ISSN: 2332-7812

DOI: 10.1212/nxi.0000000000000564